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Clarifying whether resistance-associated molecular features are induced by treatment or already present before therapy is crucial for improving patient stratification
Testicular torsion and spermatogenesis
In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (5, 6, 42)
It improves insulin sensitivity and ramps up fat oxidation
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